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The Journal of Internal Korean Medicine > Volume 28(3); 2007 > Article
The Journal of Internal Korean Medicine 2007;28(3): 544-559.
Streptozotocin 유발 당뇨 백서에 桑葉 枳殼 혼합물의 항당뇨 및 혈관탄성개선 효과
박정섭1, 박종형1, 전찬용1, 최유경1, 황귀서2, 김동우1
1경원대학교 한의과대학 내과학교실
2경원대학교 한의과대학 예방의학교실
The Anti-diabetes and Vasoelasticity Effects of Mori Folium and Aurantii Fructus in Streptozotocin Induced Type Ⅱ Diabetes Mellitus Model
Jung-sup Park1, Chong-hyeong Park1, Chan-yong Jun1, You-kyung Choi1, Gwi-seo Hwang2, Dong-woo Kim1
1Department of Internal Medicine, College of Oriental Medicine, Kyungwon University
2Department of Preventive Medicine, College of Oriental Medicine, Kyungwon University
Correspondence  Dong-woo Kim ,Tel: 02-425-3456, Fax: 02-425-3560, Email: kidow@hanmail.net
  Published online: September 30, 2007.
ABSTRACT
Objectives:
This study was designed to evaluate the anti-diabetes and vasoelasticity effects of Mori Folium and Aurantii Fructus in streptozotocin-induced type Ⅱ diabetes mellitus model.

Methods :
The anti-diabetic effect of Mori Folium and Aurantii Fructus on rats induced with diabetes by streptozotocin was investigated through analyses of changes in body weight, blood glucose, urine volume of rats, viability of human umbilical vein endothelial cells(HUVECs), and elasticity of descending thoracic aorta in rats. The subjects in this study were divided into four groups(n=15): a normal group without any treatment (Con), a normal group with Mori Folium and Aurantii Fructus treatment(Con+P), a diabetes group induced by streptozotocin(STZ), and a Mori Folium and Aurantii Fructus treatment group under diabetes induced by streptozotocin(STZ+P). Rats were administered streptozotocin to induce diabetes.

Results:
The study showed that Mori Folium and Aurantii Fructus significantly reduced highly increased blood glucose levels(p<0.01) and prevented the diabetic rats from weight loss(p<0.01) and polyurea(p<0.05). Mori Folium and Aurantii Fructus also recovered decreased viability of HUVECs(p<0.01) and damaged elasticity of aorta induced by the streptozotocin(p<0.01).

Conclusions:
It was concluded from the results that Mori Folium and Aurantii Fructus have a distinct anti-diabetes effect and they also prevent damage of blood vessel induced by diabetes, resulting in prevention of cardiovascular diseases ascribed to diabetes.
Key words: Mori Folium, Aurantii Fructus, anti-diabetes effect, streptozotocin, vasoelasticity
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