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The Journal of Internal Korean Medicine > Volume 28(2); 2007 > Article
The Journal of Internal Korean Medicine 2007;28(2): 304-320.
Effect of Astragalus Membranaceus Extract against Improvement of Myelosuppression and Quality of Life in 5-Fluorouracil Treated Mice
Chang-hyun Kwon, Hwa-seung Yoo, Sun-hwi Bang, Young-min Lee, Yeon-weol Lee, Chang-gue Son, Chong-kwan Cho
Department of East-West Cancer Center, Oriental Hospital of Daejeon University
Correspondence  Chong-kwan Cho ,Tel: 82-42-470-9132, Fax: 82-42-470-9006, Email: altyhs@dju.ac.kr
  Published online: June 30, 2007.
ABSTRACT
Objective :
To evaluate the effect of Astragalus Membranaceus Extract (AME) on myelosuppression, activity and immune modulation in 5-fluorouracil (5-FU) treated mice.

Method:
We carried out complete blood count, histological analysis of bone marrow, and cell colony forming assay for hematopoietic progenitor to evaluate the effect of AME on myelosuppression and conducted swimming test, survival rate, nitric oxide (NO) assay , 51Cr release assay in natural killer cell, mRNA expressions of IL-1β, IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ, TGF-β and GM-CSF in spleen cells to evaluate the effect of AME on quality of life (QOL).

Results:
AME improved 5-FU induced myelosuppression and peripheral blood count was recovered effectively, had significant efficacy to protect against chemotherapy induced marrow-destruction and on hematopoiesis compared with the control group, improved increase survival rate and the swimming time, had a stimulatory effect on macrophage activation and NK cell activity, and up-regulated cytokine gene transcription (IL-2, IL-6, IFN-γ) in murine immunologic system.

Conclusion:
We can conclude that AM is an effective herbal agent for improvement of myelosuppression and QOL in 5-FU treated mice.
Key words: Astragalus Membranaceus, Myelosuppression, Quality of Life, 5-Fluorouracil
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