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The Journal of Internal Korean Medicine 2006;27(4): 879-886. |
| 小靑龍湯加石膏 및 ≪石室秘籙≫小治法方이 호흡기 점액의 분비에 미치는 영향 |
| 김호, 서운교 |
| 동국대학교 한의과대학 폐계내과학교실 |
| Effects of Socheongryongtang-ga-seoggo and Prescription D on Airway Mucin Secretion |
| Ho Kim, Un-kyo Seo |
| Deptartment of Internal Medicine, College of Oriental Medicine, Dongguk University |
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Published online: December 30, 2006. |
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| ABSTRACT |
Objectives:
In the present study, the author intended to investigate whether two oriental medical prescriptions named
Socheongryongtang-ga-seoggo (SCTS) and Prescription D (P-D) significantly affect mucin release from cultured hamster
tracheal surface epithelial (HTSE) cells.
Materials and Methods :
Confluent HTSE cells were metabolically radiolabeled with 3H-glucosamine for 24 hrs and
chased for 30 min in the presence of SCTS or P-D to assess the effect of each agent on 3H-mucin release. Possible
cytotoxicities of each agent were assessed by measuring lactate dehydrogenase (LDH) release. Also, the effects of SCTS and
P-D on contractility of isolated tracheal smooth muscle were investigated.
Results:
SCTS did not affect mucin release from cultured HTSE cells, without cytotoxicity. However, P-D significantly
increased mucin release from cultured HTSE cells, with significant cytotoxicity. SCTS inhibited Ach-induced contraction of
isolated tracheal smooth muscle. P-D also inhibited Ach-induced contraction of isolated tracheal smooth muscle.
Conclusions:
The author suggests that the effects of SCTS and P-D with their components should be further
investigated and it is valuable to find, from oriental medical prescriptions, novel agents which might regulate mucin secretion
from airway goblet cells. |
| Key words:
airway, mucus, mucin, prescription D (P-D), socheongryongtang-ga-seoggo (SCTS) |
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