| 양심탕이 백서의 뇌혈류역학 변화에 미치는 영향 |
| 이정섭1, 신선호1, 전상윤2, 홍석2 |
1원광대학교 한의과대학 심계내과학교실
2동신대학교 한의과대학 심계내과학교실 |
| Effects of Yangsim-tang on the Changes of Cerebral Hemodynamics in Rats |
| Jung-sup Lee1, Sun-ho Shin1, Sang-yoon Jeon2, Seok Hong2 |
1Department of Internal Medicine, College of Oriental Medicine, WonKwang University
2Department of Internal Medicine, College of Oriental Medicine, DongShin University |
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Published online: December 30, 2006. |
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| ABSTRACT |
Objectives:
This study was performed to evaluate effects of Yangsim-tang extract (YST) on hemodynamics (regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) ) in normal rats, and effects of cyclooxygenase and guanylate cyclase under YST.
Methods :
Laser-Doppler flowmetry (LDF) measured changes of rCBF, and a data acquisition system assembled with MacLab and Macintosh measured changes of MABP.
Results:
YST significantly increased rCBF, but did not change MABP. Pretreatment with indomethacin significantly inhibited rCBF increased by YST, but pretreatment with methylene blue did not significantly inhibit rCBF increased by YST.
Conclusions:
YST increases rCBF, and the action of this response is mediated by cyclooxygenase. |
| Key words:
Hemodynamics, Cyclooxygenase, Yangsim-tang |
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