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The Journal of Internal Korean Medicine 2006;27(4): 791-796. |
| 澤瀉 시간별 投與가 Streptozotocin으로 유발된 고혈당 白鼠의 實驗的 糖尿에 미치는 影響 |
| 남정우1, 이시형1, 강미숙2, 최유경1, 전찬용1, 박종형1, 김동우1 |
1경원대학교 한의과대학 내과학교실
2경원대학교 한의과대학 침구과교실 |
| Effects of Different Lengths of Treatment with Rhizoma Alismatis on Diabetic Mellitus of Streptozotocin-Induced Hyperglycemic Rats |
| Jeong-woo Nam1, See-hyung Rhee1, Mi-suk Kang2, You-kyung Choi1, Chan-yong Jun1, Chong-hyeong Park1, Dong-woo Kim1 |
1Department of Internal Medicine, Kyungwon University Oriental Medicine Hospital
2Department of Acupuncture & Moxibustion, Kyungwon University Oriental Medicine Hospital |
| Correspondence |
Dong-woo Kim ,Tel: 02-425-3456, Fax: 02-425-3560, Email: kidow@hanmail.net
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Published online: December 30, 2006. |
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| ABSTRACT |
Objectives:
The objective of the study was to observe the effects of different treatment lengths of Rhizoma Alismatis on diabetes mellitus.
Methods :
Rats were divided into three groups: normal(non-treated group), control (group administered saline for 4, 11, and 18 days), and RA (group administered 2.45㎎/200g Rhizoma Alismatis for 4, 11, and 18 days). The experimental results were derived from the measurement of the levels of glucose, ALP, AST, ALT, creatinine and BUN in the serum from the rats on days 4, 11, and 18.
Results:
The glucose level in the serum significantly decreased on the 18th day. The ALP level in the serum did not show statistical significance. The GOT and GPT levels in the serum slightly decreased on the 4th, 11th, and 18th days, but did not show statistical significance. The creatinine level in the serum was unchanged for all of them. The BUN level in the serum did not show statistical significance.
Conclusions:
According to the above results, it is concluded that Rhizoma Alismatis has a therapeutic effect on diabetes mellitus with a longer period ofintake. As to influence upon the liver and kidney, there was no damage orside effects. |
| Key words:
Diabetes Mellitus, Rhizoma Alismatis, Streptozotocin, rat, DM |
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