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The Journal of Internal Korean Medicine > Volume 27(1); 2006 > Article
The Journal of Internal Korean Medicine 2006;27(1): 253-264.
朱子讀書丸의 아밀로이드베타로 유발된 생쥐 알츠하이머모델에 대한 효과
경혁수1, 임강현2, 고흥1
1세명대학교 한의과대학 내과학 교실
2세명대학교 한의과대학 본초학 교실
Effects of Jujadokseo-hwan on Mice with Alzheimer’s Disease Induced by Amyloid-β
Hyuk-su Kyung1, Kang-hyun Leem2, Heung Ko1
1Dept. of Internal medicine, College of Oriental medicine, Semyung University
2Dept. of Herbal medicine, College of Oriental medicine, Semyung University
Received: February 17, 2006,   Accepted: February 28, 2006,   Published online: March 30, 2006.
This research investigated effects of Jujadokseo-hwan on mice with Alzheimer’s Disease induced by amyloid-β. According to Dongyibogam, Jujadokseo-hwan can cure amnesia. Amyloid-β is believed to induce oxidative stress and inflammation in the brain, postulated to play important roles in the pathogenesis of Alzheimer’s disease. In this way amyloid- β induces Alzheimer’s Disease.

Methods :
In order to make an efficient prescription and cope with dementia, learning and memory functions of mice were tested on passive avoidance test and Y-maze task. NF-κB were measured from protein derived from the brain. RT-PCR was done for gene analysis. Primers were protein kinase B and NGF-α.

1. Jujadokseo-hwan was effective for memory capacity on passive avoidance test. but noneffective for spatial memory capacity and locomotor activity on Y-maze task. 2. The measurement of NF-κB showed upward tendancies and the result of RT-PCR showed up-regulation when given Jujadokseo-hwan by mouth.

Results suggest that Jujadokseo-hwan is effective on mice with Alzheimer's Disease induced by amyloid-β.
Key words: amyloid-β, Jujadokseo-hwan, Alzheimer's Disease, memory, learning.
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