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The Journal of Internal Korean Medicine > Volume 27(1); 2006 > Article
The Journal of Internal Korean Medicine 2006;27(1): 178-187.
三精丸의 Peroxynitrite 제거 효과
이동준, 정지천
동국대학교 한의과대학 내과학교실
Peroxynitrite Scavenging Activity of Samjunghwan
Dong-joon Lee, Ji-cheon Jeong
Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University
Correspondence  Ji-cheon Jeong ,Tel: 054-770-1265, Fax: 054-770-1500, Email: jjcjh@paran.com
Received: February 14, 2006,   Accepted: February 27, 2006,   Published online: March 30, 2006.
ABSTRACT
Objectives:
Peroxynitrite (ONOO-), ․O2 - and nitric oxide (NO) are cytotoxic species that can oxidize several cellular components such as proteins, lipids and DNA. It has been implicated in the aging process and age-related disease such as Alzheimer’s disease, rheumatoid arthritis, cancer and atherosclerosis. The aim of this study was to investigate ONOO- scavenging activities, and that of its precursors, NO and ․O2 - of Samjunghwan.

Methods :
To investigate ONOO-, NO, ․O2 - scavenging activities, fluorescent probes, namely 2',7'-dichlorodihydrofluorescein diacetate (DCFDA), 4,5-diaminofluorescein (DAF-2) and dihydrorhodamine 123 (DHR 123) were used.

Results:
Samjunghwan markedly scavenged authentic ONOO-, ․O2 - and NO. It also inhibited ONOO- induced by ․O2 - and NO which are derived from SIN-1. Furthermore, Samjunghwan inhibited ONOO-, ․O2 - and NO generation in LPS-treated ICR mouse kidney postmitochondria.

Conclusions:
These results suggest that Samjunghwan is an effective ONOO-, ․O2 - and NO scavenger, and that this substance has a potential role as an inhibitor of aging process, and in therapy against age-related diseases.
Key words: Samjunghwan, peroxynitrite, nitric oxide, reactive oxygen species
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