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The Journal of Internal Korean Medicine > Volume 27(1); 2006 > Article
The Journal of Internal Korean Medicine 2006;27(1): 16-26.
除濕順氣湯이 高脂血症 病態 모델에 미치는 影響
김정현, 조현경, 유호룡, 설인찬, 김윤식
대전대학교 한의과대학 내과학교실
The Effects of Jeseubsungi-tang on Dietary Hyperlipidemia-induced Mice
Jung-hyun Kim, Hyun-kyung Jo, Ho-rhyong Yoo, In-chan Seol, Yoon-sik Kim
Department of Internal Medicine, College of Oriental Medicine, Daejeon University, Daejon, Korea.
Correspondence  Yoon-sik Kim ,Tel: 042-229-6806, Fax: 042-254-3403, Email: yoonsik@dju.ac.kr
Received: January 27, 2006,   Accepted: February 21, 2006,   Published online: March 30, 2006.
This experiment was performed to determine the effects of the Jeseubsungi-tang(JSSGT) on hyperlipidemiainduced by hypercholesterolemic diet in mice.

Methods :
C57BL/6 mice were sensitized with a hypercholesterolemic diet for 6 weeks. Experimental group was treated with 150㎎/㎗ concentrations of JSSGT for 4 weeks (once a day).

JSSGT-treated mice showed a body weight decrease compared to normal group. JSSGT-treated mice showed a significant decrease in cholesterol, total cholesterol, triglyceride, ALT and LDL-cholesterol levels compared to hyperlipidemiainduced control group. However, HDL-cholesterol levels in JSSGT-treated group significantly increased compared to the hyperlipidemia-induced control group.

These results suggest that JSSGT is effective in treating hyperlipidemia. Because only hyperlipidemic mice were studied, further research is needed.
Key words: Hyperlipidemia, Jeseubsungi-tang, Cholesterol, Triglyceride
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