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The Journal of Internal Korean Medicine > Volume 27(1); 2006 > Article
The Journal of Internal Korean Medicine 2006;27(1): 1-15.
加味滋陰降火湯이 SHR의 혈압에 미치는 영향
백경민, 조현경, 유호룡, 김윤식, 설인찬
대전대학교부속한방병원 내과학교실
The Effect of Kamijaeumganghwatang(KJT) on Hypertension
Kyung-min Baek, Hyun-kyung Jo, Ho-rhyong Yoo, Yoon-sik Kim, In-chan Seol
Department of Internal Medicine, College of Oriental Medicine, Daejeon University, Daejon, Korea.
Correspondence  In-chan Seol ,Tel: 042-229-6805, Fax: 042-254-3403, Email: seolinch@dju.ac.kr
Received: January 16, 2006,   Accepted: February 14, 2006,   Published online: March 30, 2006.
ABSTRACT
Objective :
This study was done to investigate the effect of KJT on hypertension.

Methods :
Spontaneous Hypertensive Rats were sensitized and challenged with Kamijaeumganghwatang(KJT) for 5 weeks. Experimental group was treated with 220㎎/day/2㎖ of KJT orally and control group was treated with 2㎖/day of normal saline instead.

Results:
1. KJT significantly showed significant protection against cytotoxicity and toxicity in the liver and the kidney. 2. KJT significantly decreased the blood pressure in SHR. 3. KJT significantly decreased the levels of aldosterone in SHR. 4. KJT significantly decreased the levels of dopamine, norepinephrine and epinephrine in SHR. 5. KJT significantly decreased the levels of sodium and potassium in SHR, but it did not decrease the levels of chloride in SHR. Levels of calcium in SHR increased, but only insignificantly. 6. KJT significantly decreased the levels of IL-6 in SHR, and significantly increased the levels of IL-10 in SHR. 7. For histological effects, KJT dillated capillary vessels in the kidney, significantly decreased eosinophilic changes in heart cells, and significantly decreased endothelial damage in the aorta.

Conclusion:
These results suggest that KJT is useful in treatment of hypertension.
Key words: Kamijaeumganghwatang(KJT), Hypertension
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