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The Journal of Internal Korean Medicine 2006;27(3): 617-628. |
| 고cholesterol 식이 자발성 고혈압 白鼠에서의 加味防風通聖散이 고혈압에 미치는 영향 |
| 김종원, 조현경, 유호룡, 설인찬, 김윤식 |
| 대전대학교 한의과대학 내과학교실 |
| Effects of Kamibangpungtongsungsan on Hypertension in Spontaneous Hypertensive Rats Fed a Hyperlipidemic Diet |
| Jong-Won Kim, Hyun-kyung Jo, Ho-rhyong Yoo, In-Chan Seol, Yoon-Sik Kim |
| Department of Internal Medicine, College of Oriental Medicine, Daejeon University |
| Correspondence |
Yoon-Sik Kim ,Tel: 042-229-6806, Fax: 042-254-3403, Email: yoonsik@dju.ac.kr
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Published online: September 30, 2006. |
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| ABSTRACT |
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This experiment was performed to determine the effects of Kamibangpungtongsungsan on hypertension in spontaneous hypertensive rats fed a hyperlipidemic diet (H-SHR). The results are summarized as follows : 1. Kamibangpungtongsungsan significantly decreased the blood pressure and pulse of rats in H-SHR. 2. Kamibangpungtongsungsan significantly decreased the levels of Aldosterone in H-SHR. 3. Kamibangpungtongsungsan significantly decreased the levels of dopamine and epinephrine in H-SHR, but did not significantly reduce the levels of norepinephrine, in H-SHR. 4. Kamibangpungtongsungsan did not significantly reduce the levels of electrolytes in H-SHR. 5. Kamibangpungtongsungsan significantly decreased the TNF-α and IL-6 levels in H-SHR, but the IL-10 level increase no significant. These results suggest that the Kamibangpungtongsungsan might be usefully applied for the treatment of hypertension with hyperlipidemia. |
| Key words:
Kamibangpungtongsungsan, hypertension, catecholamine, cytokine |
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