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The Journal of Internal Korean Medicine > Volume 27(2); 2006 > Article
The Journal of Internal Korean Medicine 2006;27(2): 521-532.
加味淸上補下湯 열수 및 에탄올 추출물이 천식 관련 cytokine 분비에 미치는 영향
정승연, 이성헌, 황준호, 이건영, 김진주, 정희재, 이형구, 정승기
경희대학교 한의과대학 폐계내과학교실
The inhibitory effects of hot water and ethanol extract of Gamichungsangbohatang on cytokines related to ashtma
Seung-Yeon Jeong, Sung-Hun Lee, Joon-Ho Hwang, Kun-Young Lee, Jin-Ju Kim, Hee-Jae Jung, Hyung-Koo Rhee, Sung-Ki Jung
Division of Respiratory System, Deptartment of Internal Medicine, College of Oriental Medicine, Kyunghee University, Seoul, Korea
Correspondence  Sung-Ki Jung ,Tel: 02-958-9147, Fax: 02-958-9148, Email: jskes@unitel.co.kr
Received: June 1, 2006,   Accepted: June 20, 2006,   Published online: June 30, 2006.
ABSTRACT
Backgrounds and Objectives:
A major goal in asthma therapy isto reduce or prevent the inflammatory response associated with bronchial hyperresponsiveness, reversible airway obstruction and airway remodelling. Many studies have shown that eosinophilic infiltration is a prominent feathure in the pathophysiology of asthma. The importance of the presence of eosinophils in the airways of asthmatics has long been recognized, but the mechanism by which these cells are recruited and retained in the lung are only now being elucidated. Production of chemotactic cytokines by bronchial epithelial cells may contribute to the local accumulation of eosinophils in patients with bronchial asthma. This study was designed to investigate the inhibitory effect of extraction of herbal dicoction, Gamichungsangbohatang(GMCSBHT) on eosinophil chemotactic cytokines . Material and

Methods:
We used water and 70% ethanol extracts of GMCSBHT and pulmonary epithelial cell lines A549(human typeⅡ-like epithelial cells). We estimated cytotoxic effects of GMCSBHT, and estimated the effects of water and 70% ethanol extracts of GMCSBHT on chemokines from prestimulated A549 cells by sandwich ELISA.

Results:
Chemokines of eotaxin, IL-8 were inhibited by GMCSBHT in dose-dependent manner. And ethanol extract of GMCSBHT has more inhibitory effects on eotaxin, IL-8 than hot water extract.

Conclusions:
These findings indicate that the supression of the expression of chemokines can be accomplished by GMCSBHT treatment, so GMCSBHT may inhibit the inflammatory process by eosinophils in asthma.
Key words: Gamichungsangbohatang(GMCSBHT), eosinophil, asthma, cytokine
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