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The Journal of Internal Korean Medicine > Volume 27(2); 2006 > Article
The Journal of Internal Korean Medicine 2006;27(2): 327-335.
The Effects of Hominis Placenta Hydrate (HPH) on the Bone Marrow Failure Induced by 5-Fluorouracil
Chang Woo CHOI1, Jang Woo SHIN2, Jung Hyo CHO1, Chang Gue SON1, Yong Yeon Lee1, Yeon Weol LEE1, Hwa Seung YOO1, Nam Heon LEE1, Yun Dam Hee1, Chong Kwan CHO1
1Department of Internal Medicine College of Oriental Medicine, Daejon University, Daejeon, Korea
2Institute of Traditional Medicine and Bioscience, Daejeon. University, Daejeon, Korea
Correspondence  Chong Kwan CHO ,Tel: 82-42-470-9661, Fax: 82-42-229-6968, Email: longrain@dju.ac.kr
Received: April 15, 2006,   Accepted: June 13, 2006,   Published online: June 30, 2006.
ABSTRACT
Aim:
To examine the efficacy of Hominis Placenta Hydrate (HPH) on the hemopoiesis in a myelosuppression model system.

Methods:
Mice were injected with 5-Fluorouracil (5-FU) intraperitoneally and were administered with 200 mg/kg and 1000 mg/kg of HPH. Peripheral blood was analyzed at 5, 9, and 13 days. Histopathologic examination of bone marrow was performed at 5 days after 5-FU injection. The expression of cytokine involved in hemopoiesis was examined by using ELISA kit.

Results:
The hematology data demonstrated that the treatment of all the agents augmented monocytes and leucocytes counts in the peripheral blood WBC and platelet in HPH treated group were significant increased compared with control group. Also, cell numbers of RBC and Hb were restored. In HPH treated group, expression of IL-3, GM-CSF was significant increased But not TPO.

Conclusions:
Based on the above results, it is suggested that Hominis Placenta Hydrate is an effective remedy for the bone marrow failure and myelosuppression occurring during chemotherapy
Key words: Hominis Placenta hemopoiesis; IL-3; GM-CSF
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