| 射干麻黃湯 및 <石室秘籙＞逆醫法方이 호흡기 점액의 분비에 미치는 영향 |
| 심성흠, 이주일, 정영재, 서운교 |
| 동국대학교 한의과대학 폐계내과학교실 |
| The Effects of Saganmahwang-tang and prescription C on airway mucin secretion |
| Sung-Heum Sim, Ju-il Lee, Young-Jae Jung, Woon-Gyo Suh |
| Deptartment of Internal Medicine, College of Oriental Medicine, Dongguk University |
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Received: February 13, 2006, Accepted: February 25, 2006, Published online: June 30, 2006. |
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| ABSTRACT |
Objectives:
This study was done to investigate whether two oriental prescriptions, saganmahwang-tang (SMT) and prescription C (P-C) significantly affect mucin release from cultured hamster tracheal surface epithelial (HTSE) cells.
Methods :
Confluent HTSE cells were metabolically radiolabeled with 3H-glucosamine for 24 hrs and chased for 30 min in the presence of SMT or P-C to assess the effect of each agent on 3H-mucin release. Possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase (LDH) release. Also, the effects of SMT and P-C on contractility of isolated tracheal smooth muscle were investigated.
Results:
SMT significantly inhibited mucin release from cultured HTSE cells, without cytotoxicity. P-C significantly increased mucin release from cultured HTSE cells, with significant cytotoxicity. SMT inhibited Ach-induced contraction of isolated tracheal smooth muscle. P-C did not affect Ach-induced contraction of isolated tracheal smooth muscle.
Conclusion:
Results suggest that SMT and P-C have regulating effects on mucin secretion from airway goblet cells. Further investigation is needed, because of the value in finding novel agents to this purpose, and these oriental medical prescription have potential for such a role. |
| Key words:
airway, mucus, mucin, saganmahwang-tang (SMT) and prescription C (P-C) |
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