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The Journal of Internal Korean Medicine > Volume 40(1); 2019 > Article
The Journal of Internal Korean Medicine 2019;40(1): 70-88.
doi: https://doi.org/10.22246/jikm.2019.40.1.70
췌장암에 대한 국내 한의학 연구 동향 고찰 - 국내 한의학 논문을 중심으로 -
한가진1,2, 정하영1, 박은주1,2, 이아름1,2, 이준명1,2, 성 신1, 김성수1
1소람한방병원
2소람한의약연구소
Review of Domestic Research on Korean Medicine for Pancreatic Cancer
Ga-jin Han1,2, Ha-yeong Jeong1, Eun-joo Park1,2, A-reum Lee1,2, Jun-myung Lee1,2, Sin Seong1, Sung-su Kim1
1Soram Hospital of Korean Medicine
2Soram Korean Medicine Research Institute
Correspondence  Ga-jin Han ,Tel: +82-70-4803-6648, Fax: +82-70-8282-7001, Email: kmdhgj@soram.kr
Received: March 7, 2019,   Accepted: March 29, 2019,   Published online: March 30, 2019.
ABSTRACT
Objective:
This study investigated the trends in pancreatic cancer research on Korean medicine in order to establish a direction for further study.

Methods:
Pancreatic cancer research on Korean medicine was reviewed using databases such as OASIS, KoreanTK, KISS, RISS, KISTI, and NDSL. The search terms were “pancreatic cancer” “Korean medicine,” and “herbal medicine.” There was no restriction on publication dates, and the reviewed studies were analyzed according to the type of research.

Results:
Nineteen studies were reviewed. The numbers and types of research were as follows: 9 clinical studies including case reports, 2 review studies, and 8 in vitro studies; there was no in vivo study. Among the clinical research were 3 descriptive studies and 6 case reports. The baseline characteristics and quality of life of pancreatic cancer patients were analyzed in the descriptive studies. In the case reports, interventions such as herbal medicine, pharmacopuncture, and acupuncture were used. Research articles on the review of pancreatic cancer were titled “Preliminary Study for Development of Korean Medicine Clinical Practice Guideline for Pancreatic Cancer” and “Systemic Review on the Tumor Dormancy Therapy.” Cell lines such as PANC-1, MIA PaCa-2, and AsPC-1 were used for in vitro studies. These studies have reported decreased cell viability, induced apoptosis, and changes in cancer-related gene expression.

Conclusion:
Through this review, we found that using Korean medicine for treating pancreatic cancer is applicable. However, due to overall limited the number of study, the benefit of Korean medicine for pancreatic cancer may be substantiated to a limited degree. Better methodological quality and large controlled trials are expected to further quantify the therapeutic effect of Korean medicine.
Key words: pancreatic neoplasm, Korean traditional medicine, review
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