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The Journal of Internal Korean Medicine > Volume 40(1); 2019 > Article
The Journal of Internal Korean Medicine 2019;40(1): 154-163.
doi: https://doi.org/10.22246/jikm.2019.40.1.154
폐경기 안면홍조 증상에 대한 한약처방 이선탕의 투여경과 및 이상반응 보고 : 증례보고 및 문헌고찰
김보민1, 조희근2
Administration Progression and Adverse Event Report of Er-Xian Decoction for Menopausal Hot Flushes: Case Report and Review of Literature
Bo-min Kim1, Hee-geun Jo2
1Chung-Yeon Korean Medical Hospital
2Chung-Yeon Central Institute
Correspondence  Hee-geun Jo ,Tel: 062-371-1075, Fax: 062-371-1074, Email: jho3366@hanmail.net
Received: March 9, 2019,   Accepted: March 27, 2019,   Published online: March 30, 2019.
We report on the administration progression and adverse event of Er-Xian decoction for menopausal hot flushes. A hot flush is a rapid and intense heat-dissipation reaction that involves considerable sweating, enlargement of the peripheral blood vessels, and internal body heat. Er-Xian decoction is a prescription for treating menopausal hot flush symptoms in postmenopausal women. We report administration progression and adverse event of Er-Xian decoction for menopausal hot flush.

We used the Menopause Rating Scale and Menopause-Specific Quality of Life questionnaire to evaluate the progression of hot flushes, and we conducted a literature review to determine the effective dosage of Er-Xian decoction.

In all cases, Facial hot flushes and evaluation variables were improved by the administration of EXD. However, in Case 1, a rise of liver function indexes which may be related to EXD administration was observed.

Considering that menopausal flushing usually lasts for several years, The resluts are meaningful that the short-term administration of EXD led to improvement of symptoms. In order to further use EXD in the future, it will be necessary to conduct follow-up studies on the subject of safety verification, such as repeated dose toxicity studies.
Key words: menopause, menopausal syndrome, hot flush, herbal medicine, Er-xian decoction
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