| Mouse의 십이지장 점막 염증에 대한 사삼맥문동탕의 면역반응 연구 |
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| The Effects of Sasammaickmoondong-tang against Duodenal Mucosal Lesions |
| Jun-Hyuk Choi, Seong-Woo Lim |
| Department of Internal Medicine, College of Oriental Medicine, Dongguk University |
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Received: April 10, 2003, Accepted: May 10, 2003, Published online: June 30, 2003. |
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| ABSTRACT |
Objectives:
This study was carried out to investigate the effects of Sasammaickmoondong-tang(SME) on duodenal mucosal lesions induced by indomethacin in mouse.
Methods :
The normal group is that no inflammation elicitated mouse. Control group is that gastro-inflammation elicitated mouse. Sample group is that SME administered mouseice after gastro-inflammation elicitation.
Results:
In the common morphology and histochemical change, control group was observed various injury - mucous surface cell, micro-villi, paneth cell, surface epithelial cell, goblet cell - by hemorrhagic erosion, while sample group was as same as normal group. In the immunohistochemical change, the distributions of COX-1, Bcl-2, and BrdU treated with SME noticeably increased than control group(p<0.05). The distributions of TUNEL, NF- κB, COX-2, IL-2R-α , NK-1.1, ICAM-1, and CD11b/18 treated with SME noticeably decreased than control group(p<0.05). And the distribution of SBA was as same as normal group.
Conclusion:
According to the above results, it is supposed that Sasammaickmoondong-tang is applicable to duodenal mucosal lesions. |
| Key words:
Sasammaickmoondong-tang, duodenal mucosal lesions |
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