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The Journal of Internal Korean Medicine 2003;24(1): 33-43. |
| B 淋巴球와 肥滿細胞에서 牡丹皮抽出物의 抗알러지 作用에 關한 硏究 |
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| The effects of the abstracts from Moutan Cortex on an anti-allergic action on B cells and mast cells of the BALB/C mouse |
| Sung-Ik Jang, Sok-Chang Jeen, Sung-Kyun Kim, Han-Bae Lee, Seung-Hee Lee, Young-Bae Seo, Yong-Gu Lee, Young-Chul Lee |
1Hae Dang Hosptial of Oriental Medicine
2Dong Seo Hosptial of Oriental Medicine
3College of Oriental Medicine, Taejon University, Taejon, Korea |
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Received: September 26, 2002, Accepted: December 24, 2002, Published online: March 26, 2003. |
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| ABSTRACT |
Objective :
This study was carried out for the purpose of proving the effect of anti-allergic efficacy on B cells and the mast cells of the BALB/C mouse by the abstraction from a Moutan cortex.
Methods and Results :
In order to know what the effect of an abstraction from Moutan cortex and about the expression of CD23 and IgE, IC-2 cell (mouse mast precursor cells that was dependent on IL-3 , it was necessary to be activated. We then analyzed it from the flow of cytometry on the increase and the divorce of the B cells activated by anti-CD40. In order to know what the effect of it was on the organization of cytokine gene expression from the increase and divorce of the B cells and allergic acting by Moutan cortex, we found it necessary to examine the IC-2 cells and B cells. At the same time, as we examined the histamine release of IC-2 cells by ELISA method, we also examined the effect of Moutan cortex on the increase and divorce of the B cells by 3H-thymidine uptake method. We then analyzed the release of IL-4, IgE and histamine.
Conclusions:
As a results, Moutan Cortex promoted blood supply by extending the blood vessel of nasal mucous, which was contracted by the hypertrophied nasal mucous. |
| Key words:
Moutan cortex, B cells, the mast cells, Anti-allergic action |
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