| 茵蔯淸肝湯이 肝保護및 纖維化 抑制에 미치는 影響 |
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| Inhibitory Effect of Injinchunggantang(Yinchenqinggan-tang) on Hepatic Sclerosis |
| Hyun-Suk Seung, Young-Chul Kim, Jang-Hoon Lee, Hong-Jung Woo |
| Department of Internal Medicine, College of Oriental Medicine, Kyunghee University |
| Correspondence |
Young-Chul Kim ,Tel: 02-958-9118, Fax: 02-958-9120, Email: soongah@netsgo.com
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Received: September 26, 2002, Accepted: December 20, 2002, Published online: March 30, 2003. |
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| ABSTRACT |
Objective :
The aim of this study is to investigate the inhibitory effect of Injinchunggantang on hepatic sclerosis induced by CCl4.
Methods :
Weight, liver function test and complete blood cell count, gross findings, and findings on liver tissue of the past(Hematoxylin & Eosin stain, Masson-Trichrome stain) were studied.
Results:
When it comes to the change of rats body weight, The CCl4+Injinchunggantang group lost far less weight than The CCl4-only group. In the liver function test, which is focused on various areas such as total cholesterol, alkaline phosphotase, albumin, aspartate transaminase, alanine transaminase, The CCl4+Injinchunggantang group was much more closer to normal limit than the CCl4- only group. In the complete blood cell count, including white blood cell, red blood cell, hemoglobin, hematocrite, platelet, The CCl4+Injinchunggantang group significantly closer to normal limit than CCl4-only group. In the gross findings of hepatic fibrosis models, Injinchunggantang showed inhibitory effect on hepatic fibrosis in the order. In the past findings of hepatic fibrosis models in Hematoxylin & Eosin, Masson-Trichrome staining, the liver in CCl4-only group showed atrophy and necrotic change with white nodules, whereas that of CCl4+Injinchunggantang group showed lesser significant change with the well_preserved tone of the tissue. In the extent of the inhibition of the hepatic fibrosis, the Injinchunggantang group showed statistically significant inhibitory effect(p<0.05) in the sclerosis model.
Conclusions:
These results show that Injinchunggantang have inhibitory effect on hepatic sclerosis induced by CCl4 and further ultimately prevent liver cirrhosis. To obtain more credible results in this experiment, the invention of a new experimental model more similar to human hepatic sclerosis is still needed. |
| Key words:
Injinchunggantang, hepatic sclerosis, CCl4 |
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