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The Journal of Internal Korean Medicine 2001;22(1): 39-44. |
| 도인,소목이 Endotoxin으로 유발된 어혈병태모델에 미치는 영향 |
| 고승희, 전찬용, 박종형, 한양희, 김동우, 박세기, 이청정혜, 고재철, 최유경, 백은기, 홍의실, 박지윤 |
| 경원대학교 내과학교실 |
| The Experimental study of Persicae Semen and Caesalpiniae Lignum on the endotoxin induced thrombosis |
| Seung-Hi Go, Chan-Yong Jun, Jong-Hyung Park, Yang-hi Han, Dong-U Kim, Se-Gi Park, Chung-Jung-Hye Lee, Jae-Chul Go, You-Kyung Choi, Eun-Gi Baek, Ui-Sil Hong, Ji-Yun Park |
| Department of Internal Medicine, College of Oriental Medicine, Kyung-Won University |
| Correspondence |
Seung-Hi Go ,
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Received: April 27, 2001, Accepted: June 7, 2001, Published online: March 30, 2001. |
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| ABSTRACT |
Objective :
This experimental study was carried out to investigate the effects of Persicae Semen(PS) and Caesalpiniae Lignum(CL) on the intravascular coagulation which is considered as thrombosis.
Methods :
Rats were pretreated orally with PS and CL extracts(PS: 8.45 mg/100g, CL: 4.4 mg/100g), and 1hour later, to induce thrombosis, were given an endotoxin(0.01 mg/100g) injection into the caudal vein. After 4hours we collected blood by cardiac puncture and measured the platelet count, the prothrombin time, the level of fibrinogen and the FDP(fibrinogen degradation product).
Results:
PS and CL supressed the decrease of the Platelet count and the prolongation of prothrombin time. In these factors, both groups showed significant effect. Both groups supressed the decrease of the fibrinogen level and the increase of the FDP level. But, only the PS group showed a significant effect on the fibrinogen level, and only the Cle CL group showed a significant effect on FDP level.
Conclusions:
PS had significant effects on the platelet count, the prothrombin time, and the FDP level. CL had significant effects on the platelet count, the prothrombin time, and the fibrinogen level. Therefore, Persicae Semen and Caesalpiniae Lignum seem to be applicable to treating the diseases related to thrombosis. |
| Key words:
Persicae Semen, Caesalpiniae Lignum, thrombosis |
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