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The Journal of Internal Korean Medicine 2013;34(3): 256-266. |
| 후박의 항우울 효과에 대한 실험적 연구 |
| 유주연1, 우찬1, 정혜련1, 최정훈2, 이언정1 |
1원광대학교 한의과대학 내과학교실
2함소아 한의원 |
| Experimental Study on the Antidepressant Effects of Magnolia Officinalis, Extracts |
| Ju-yeon You1, Chan Woo1, Hye-ryon Jeong1, Jung-hoon Choi2, Un-jung Lee1 |
1Dept. of Internal Medicine, College of Oriental Medicine, Won-Kwang University
2Hamsoa Oriental Medical Clinic |
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Published online: September 30, 2013. |
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| ABSTRACT |
Objectives:
The purpose of this study was to investigate the protective effects of Magnolia Officinalis extracts on the animal model of depression induced by immobilization stress.
Methods :
The subjects were divided into 4 groups : normal, saline solution-administered during immobilization stress, 200 mg/kg of magnolia extracts-administered (magnolia extract 200), and 400 mg/kg of magnolia extracts- administered (magnolia extract 400). During 2 days of immobilization stress treatment, they underwent forced swimming test (FST) and tail suspension test (TST). The number of serotonin (5-HT) immunostained nuclei in the dorsal raphe nucleus regions was measured by immunohistochemistry. Superoxide dismutase (SOD) and glutathione peroxidase (GPX) in blood were measured.
Results:
In FST, magnolia-administered groups showed significantly decreased immobilization. In TST, the magnolia extract 400 group showed decreased immobilization. The stress group showed significantly decreased number of 5-HT immunostained nuclei in the dorsal raphe nucleus regions, while magnolia extract 400 group showed increased number of 5-HT immunostained nuclei. Stress group showed decrease in serum level of SOD and GPX, while the magnolia extract 200 group showed increase in serum level of SOD and GPX.
Conclusions:
These results suggest potent effectiveness of magnolia extracts in the treatment of depression. |
| Key words:
antidepressant, Magnolia Officinalis, forced swimming test, tail suspension test |
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