Effects of Individual Herbal Components of <i>Yijintang-gamibang</i>
in the Rat Reflux Esophagitis

Lee, Sang-tae; Kwak, Min-a

The Journal of Internal Korean Medicine > Volume 34(2); 2013 > Article

Original Article

The Journal of Internal Korean Medicine 2013;34(2): 165-177.

逆流性食道炎에 대한 二陳湯加味方構成個別 한약재의 效果

이상태, 곽민아

대구한의대학교 한의과대학 내과학교실

Effects of Individual Herbal Components of Yijintang-gamibang in the Rat Reflux Esophagitis

Sang-tae Lee, Min-a Kwak

Dept. of internal Medicine, College of Oriental Medicine, Daegu Hanny University

Correspondence

Min-a Kwak ,Tel: 053-770-2176, Fax: 053-770-2189, Email: nari003@hanmail.net

Published online: June 30, 2013.

ABSTRACT

Objectives:
The object of this study was to observe the protective effects of 8 types of individual herbal components of Yijintang-gamibang, on the reflux esophagitis (RE) in rats as compared with omeprazole.

Methods :
Each 100 mg/kg individual herbal component was orally pretreated, at 1 hr before and 6 hrs after pylorus and forestomach ligation, the changes on the esophageal lesion areas, gastric volumes, acid and pepsin outputs, antioxidant effects, esophageal total hexose and sialic acid contents were observed with changes on the esophageal histopathology. The results were compared with an omeprazole 10 mg/kg treated group.

Results:
Pylorus and forestomach ligation-induced RE were inhibited by treatment of all 8 herbal components and omeprazole except for Pinella Rhizoma and Massa Meicata Fermentata, in order of Atractylodis Rhizoma, Citri Pericarpium, omeprazole, Glycyrrhizae Radix, Hordei Fructus Germiniatus, Holelen and Citri Pericarpium, as compared with RE control. Pinella Rhizoma and Massa Meicata Fermentata did not show any favorable protective effects against RE nor antioxidant effects in the present study.

Conclusions:
The main active herbal components showing favorable protective effects on RE of Yijintang-gamibang mediated by antioxidant effects, were Atractylodis Rhizoma, Citri Pericarpium, Glycyrrhizae Radix, Hordei Fructus Germiniatus, Holelen and Citri Pericarpium. Furthermore Atractylodis Rhizoma and Citri Pericarpium showed more favorable protective effects as compared with omeprazole, therefore, it is expected that Atractylodis Rhizoma and Citri Pericarpium have potential as new alternatives or safe therapeutics against RE.

Key words: Reflux esophagitis, Yijintang-gamibang (Erchentang-jiaweifang), Atractylodis Rhizoma, Citri Pericarpium, omeprazole