石膏가 streptozotocin으로 유발된 rat의 糖尿病性 腎症에 미치는 影響 |
홍광해1, 이권호1, 정기훈1, 김용성1, 이현주2 |
1동신대학교 한의과대학 신계내과학교실 2제인한방병원 한방내과 |
The Effects of Gypsum on Streptozotocin-induced Diabetic Nephropathic Rats |
Gwang-hae Hong1, Kwun-ho Lee1, Gi-hoon Jeong1, Young-seong Kim1, Hyun-ju Lee2 |
1Dept. of Internal Medicine. College of Oriental Medicine, Dongshin University 2Oriental Internal Medicine, Jein Hospital of Oriental Medicine |
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Published online: December 30, 2008. |
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ABSTRACT |
Objectives: The aim of present study was to investigate recovery effects of gypsum, which has been used clinically in diabetes therapy.
Methods : We established three groups, normal, control, and gypsum, and assigned 6 rats to each group. The normal group was not treated by any process and fed normal saline. The control & gypsum groups were administered streptozotocin(STZ) to induce diabetes. Gypsum extract was orally administered to the gypsum group for 10 days. After 8 weeks, the rats were sacrificed and their body weight, 24hrs urinary protein excretion, glucose, albumin, BUN, creatinine, total-cholesterol, LDL-cholesterol, triglyceride in blood, level of glycation end-product (AGE) and transforming growth factor (TGF-β1) in serum were measured. Morphological profiles and morphometric studies of the kidney cortex, renal transforming growth factor (TGF-β1) expression, macrophage/monocyte antigen (ED-1), and type IV collagen expression were studied.
Results: The following results were obtained. The protein amount in urine per 24hrs of the gypsum-treated group as compared to the control was significantly reduced. The BUN and creatinine level in serum of the gypsum-treated group as compared to the control was significantly inhibited. The construction change in the kidneys of the gypsum-treated group as compared to the control was significantly inhibited. The factor of the gypsum-treated group as compared to the control was significantly inhibited, which induced the structural change in the kidneys.
Conclusions: The above results suggest that gypsum partially improved kidney function. |
Key words:
Gypsum, Streptozotocin, Diabetic Nephropathic Rats |
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