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The Journal of Internal Korean Medicine 2007;28(2): 209-216. |
| 正傳加味二陳湯이 흰쥐의 胃排出能에 미치는 影響 |
| 남효익1, 김회영1, 손현수1, 임성우2 |
1광동한방병원 내과
2동국대학교 한의과대학 한방내과교실 |
| Effect of Jungjungamiyjintang(JGT) on Gastric Emptying of Spregue-Dawley rat |
| Hyo-ik Nam1, Hoi-young Kim1, Hyun-soo Son1, Sung-woo Lim2 |
1Department of Internal Medicine, Kwang-Dong Oriental Medicine Hospital
2Department of Oriental Internal Medicine, College of Oriental Medicine, Dongguk University |
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Published online: June 30, 2007. |
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| ABSTRACT |
Background & Objective :
The herbal medicine JGT has been used for the treatment of functional dyspepsia, generally categorized as a gastric disease. However, its effect and mechanism are not yet well known. Therefore, the effects of JGT on gastric emptying in rats was investigated to know its effectiveness and mechanism.
Methods :
Gastric emptying effect was measured by the number of glass beads expelled from the stomach within an hour after glass beads and test drugs were administered. In another series of experiments to evaluate the mechanisms of JGT under delayed conditions, the rats were treated with atropine sulfate
Results:
Intragastric administration of JGT significantly increased gastric emptying of glass beads Under the gastric emptying delayed with atropine sulfate, JGT insignificantly increased gastric emptying of glass beads.
Conclusions:
These suggest that JGT has a significant effect to stimulate gastric emptying. Results are indicative of JGT as an especially effective remedy for dysmotility-like functional dyspepsia with impaired reservoir function such as gastric adaptive relaxation. |
| Key words:
JGT, Gastric emptying, Atropine sulfate |
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