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The Journal of Internal Korean Medicine 2006;27(4): 915-924. |
| 凉膈散火湯이 고지혈증 흰쥐의 중대뇌동맥 폐쇄에 의한 뇌경색에 미치는 영향 |
| 오경환, 이원철 |
| 동국대학교 한의과대학 내과학교실 |
| Neuroprotective Effect of Yanggyuksanhwa-tang on Cerebral Infarction Induced by MCAO in Hyperlipidemic Rats |
| Kyung-hwan Oh, Won-chul Lee |
| Deptartment of Oriental Internal Medicine, Graduate School of Oriental Medicine, Dongguk University |
| Correspondence |
Won-chul Lee ,Tel: 031-961-9003, Fax: 031-961-9009, Email: heart@duih.org
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Published online: December 30, 2006. |
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| ABSTRACT |
Objectives:
Yanggyuksanhwa-tang is a prescription used for cerebral infarction clinically it is known that this formula reduces body fat, serum cholesterol and triglyceride in hyperglycemia and obesity patients. According to previous research data, controlling these types of lipid is considered to decrease the risk of cerebral infarction. Based on this fact, we investigated the relationship between hyperlipidemia and cerebral infarction, and the effect of Yanggyuksanhwa-tang, on hyperlipidemic cerebral infarction.
Methods :
We induced cerebral infarction by middle cerebral artery occlusion (MCAO) in high-fat diet rats, and the rats were administered Yanggyuksanhwa-tang.
Results:
Infarct area and serum lipid were measured, and the level of elements such as c-Fos, Bax and caspase-3 in penumbra of infarct were expressed by immunohistochemical staining.
Conclusions:
Yanggyuksanhwa-tang showed neuroprotective effect through preventing neuronal cell apoptosis as well as reducing serum lipid level in hyperlipidemic condition. |
| Key words:
Yanggyuksanhwa-tang, hyperlipidemic condition, MCAO, infarct volume, neuroprotective effect. |
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